Mitochondrial Dysfunction in Parkinson's Disease
نویسندگان
چکیده
منابع مشابه
Mitochondrial Dysfunction in Parkinson's Disease
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder characterized by numerous motor symptoms, including bradykinesia, hypokinesia, rigidity, resting tremor, and postural instability and non-motor symptoms, such as autonomic dysfunction, sleep abnormalities, depression, and dementia [1-3]. The motor clinical manifestations are the preferential loss of dopaminergic (DA...
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(mtDNA) disease and the frequency of cardiac involvement, at least 1 in 10–15,000 of the general population will be affected.4 In 1991, the first mtDNA point mutation in the MT-TL1 gene associated with an MCM was described.5 Since then, several mutations, mostly in mitochondrial tRNA genes, have been associated with different MCM phenotypes. At the end of the 20th century, mutations in several ...
متن کاملMitochondrial Dysfunction in Parkinson’s Disease
It is clear from a striking convergence of human tissue studies, neurotoxin models, and genetic models that mitochondrial dysregulation plays a central pathogenic role in Parkinson’s disease (PD) and related neurodegenerative conditions. Impaired mitochondrial quality could result from both increased damage and decreased ability to repair or clear damaged mitochondria. In particular, common def...
متن کاملMitochondrial Dysfunction in Parkinson’s Disease
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متن کاملMitochondrial dysfunction and Alzheimer's disease.
To date, one of the most discussed hypotheses for Alzheimer's disease (AD) etiology implicates mitochondrial dysfunction and oxidative stress as one of the primary events in the course of AD. In this review we focus on the role of mitochondria and mitochondrial DNA (mtDNA) variation in AD and discuss the rationale for the involvement of mitochondrial abnormalities in AD pathology. We summarize ...
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ژورنال
عنوان ژورنال: Parkinson's Disease
سال: 2011
ISSN: 2042-0080
DOI: 10.4061/2011/716871